Vaginal Estradiol Cream
Targeted relief for dryness and discomfort, right where you need it.
- For vaginal dryness, discomfort during sex and urinary urgency
- Applied with an applicator
Card authorized at checkout. Charged only if a provider approves.
Product images are for illustration only. Actual packaging may vary.
Vaginal Estradiol Cream is a prescription drug that contains estradiol and is used to treat vaginal dryness, discomfort during intercourse and urinary symptoms of menopause. Vaginal estrogen carries the same warnings as other estrogen products, including risks of blood clots, stroke and certain cancers. Report any unusual vaginal bleeding to your provider. See Important Safety Information.
The short version.
What is Vaginal Estradiol Cream?
A low-dose estradiol cream applied inside the vagina to treat vaginal dryness, discomfort during intercourse and urinary symptoms of menopause.
What makes Vaginal Estradiol Cream different?
It acts locally on vaginal and urinary tissue, with minimal absorption into the rest of the body.
How much does Vaginal Estradiol Cream cost?
Starting at $63/mo with the 3-month supply ($189 billed every 3 months), or $110 monthly. No membership fee.
Three simple
steps.
Get prescribed
Complete a secure online visit, and a licensed provider reviews your health history.
Apply with the applicator
Usually every day for the first week or two, then a few times a week.
Check in
Your provider follows your progress and adjusts your plan if needed.
From your phone
to your door.
Your card is authorized at checkout, but you are only charged if a provider approves your treatment.
Complete a short online visit with a few health questions
Hear from your provider
Most orders arrive within a few business days of approval, with tracking sent when your order ships
Begin treatment, with your care team a message away
Find the
right fit.
Your provider confirms which option is appropriate for you.
| Treatment | What it is | Price |
|---|---|---|
| Estradiol Patch Featured | Estradiol · weekly skin patch | Starting at $109.67/moBilled $329 every 3 months · Recommended · 3-month supply (or $133 monthly) |
| Estradiol Pill | Estradiol · daily tablet | Starting at $59.67/moBilled $179 every 3 months · Recommended · 3-month supply (or $99 monthly) |
| Estradiol Cream | Compounded estradiol · daily skin cream | Starting at $66.33/moBilled $199 every 3 months · Recommended · 3-month supply (or $110 monthly) |
| Vaginal Estradiol Cream | Estradiol 0.1 mg/g · vaginal cream with applicator | Starting at $63/moBilled $189 every 3 months · Recommended · 3-month supply (or $110 monthly) |
| Progesterone | Progesterone · capsule at bedtime | Starting at $66.33/moBilled $199 every 3 months · Recommended · 3-month supply (100 mg) (or $99 monthly) |
Questions, answered.
Will it help with hot flashes?
No. It treats vaginal and urinary symptoms. For hot flashes, ask about the patch, pill or skin cream.
Can I use it with the patch or pill?
Yes. Many women use both, which is our Complete Care bundle.
When will I notice a difference?
Response to treatment varies from person to person. Your provider follows your symptoms at each check-in and adjusts your treatment as needed.
Do I need a prescription?
Yes. Complete a short online visit to see if this treatment is right for you. A licensed provider reviews your answers and decides whether it's appropriate to prescribe.
Who makes the treatment decision?
Licensed providers make all consultation and prescribing decisions. Purchasing does not guarantee a prescription. Prescriptions are issued only after a licensed provider reviews your information and determines that treatment is appropriate.
What the research says.
The studies discussed here may involve different formulations, doses, delivery methods, or patient populations from the treatment offered. They do not establish the safety or effectiveness of this specific compounded product. Compounded medications are not FDA-approved; FDA does not review their safety, effectiveness, or quality before marketing.
The 2022 hormone therapy position statement of The North American Menopause Society.
What was studied. A professional evidence synthesis (not a single trial) of menopausal hormone therapy.
What researchers found. Menopausal hormone therapy is the most effective treatment for hot flashes and night sweats. Low-dose vaginal estrogen is an established treatment option for menopause-related vaginal dryness and discomfort when nonprescription measures are insufficient.
How it relates to this treatment. Your clinician reviews your symptoms, medical history, and individual risks to determine whether treatment is appropriate. Patients with a uterus generally need endometrial protection (progesterone) when using systemic estrogen. Bundles combine individual treatments; the bundles themselves have not been studied as products.
“The 2022 hormone therapy position statement of The North American Menopause Society.” Menopause, 2022. PMID: 35797481.
What to know before starting Vaginal Estradiol Cream.
Other ways
we can help.
Vaginal Estradiol Cream is a prescription drug that contains estradiol and is used to treat vaginal dryness, discomfort during intercourse and urinary symptoms of menopause. Vaginal estrogen carries the same warnings as other estrogen products, including risks of blood clots, stroke and certain cancers. Report any unusual vaginal bleeding to your provider.
We serve patients in 46 states. We do not currently provide services in Alaska, Mississippi, New Jersey or Texas. Availability can vary by product, depending on whether the dispensing pharmacy is licensed to ship to your state.
Licensed providers make all consultation and prescribing decisions. Purchasing does not guarantee a prescription. Prescriptions are issued only after a licensed provider reviews your information and determines that treatment is appropriate. Your card is authorized at checkout, but you are only charged if a provider approves your treatment.