Support Your Own Testosterone (enclomiphene)
What is enclomiphene?
Enclomiphene is a daily oral medication prescribed for men with symptoms of low testosterone. It helps the body make more of its own testosterone. It is a compounded medication. Compounded medications may be prescribed under federal law, but they are not FDA-approved, and the FDA does not review them for safety, effectiveness or manufacturing quality.
Who should not use it?
Do not use enclomiphene if you:
- Have liver disease
- Have a pituitary tumor or other pituitary condition
- Have thyroid or adrenal problems that aren’t controlled
- Have a history of blood clots
- Are allergic to enclomiphene, clomiphene or any inactive ingredient
- Are a woman
How should I use it?
- Take one tablet by mouth each day, at about the same time.
- Don’t stop or change your dose without talking to your care team.
What should I tell my provider first?
Tell your provider about every medicine you take, including over-the-counter supplements, and if you have or have had liver problems, blood clots, vision problems, a pituitary or brain condition, thyroid or adrenal problems, or heart disease.
What are the most serious side effects?
If you have a medical emergency, call 911. Stop taking enclomiphene and get medical help right away if you have:
- Vision changes, such as blurring, spots or flashes of light
- Signs of a blood clot, such as leg pain or swelling, chest pain or shortness of breath
- A sudden severe headache
What are the most common side effects?
Headache, hot flashes, nausea, mood changes and dizziness.
Other important information
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
This summary provides basic information about enclomiphene but does not include everything known about this medicine. Your ReformedRx provider can answer any questions about side effects before you start treatment. Please also read the information that comes with your prescription each time it’s filled.
Estradiol and Progesterone (Patch, Pill, Cream, Vaginal Cream, Progesterone, Bundles)
What are these products?
Estradiol is an estrogen used to treat menopause symptoms, such as hot flashes and night sweats (patch, pill and skin cream), and vaginal dryness and discomfort (vaginal cream). Progesterone is taken with estrogen by women who still have a uterus. Estradiol and progesterone are FDA-approved for these uses. The Estradiol Cream is a compounded medication. Compounded medications may be prescribed under federal law, but they are not FDA-approved, and the FDA does not review them for safety, effectiveness or manufacturing quality.
Most important information about estrogen therapy
- Using estrogen alone may increase your chance of getting cancer of the uterus (endometrial cancer). Women with a uterus take progesterone to lower this risk. Report any unusual vaginal bleeding right away.
- Estrogen, with or without progesterone, should not be used to prevent heart disease, heart attack, stroke or dementia.
- Estrogen, with or without progesterone, may increase the chance of heart attack, stroke, breast cancer and blood clots. Women 65 and older may have a higher chance of dementia.
- Use the lowest dose that works, for as long as you need it. Talk to your provider at least once a year about whether you should continue.
Who should not use them?
Do not use estradiol if you:
- Have unexplained vaginal bleeding
- Have or have had breast cancer or another estrogen-sensitive cancer
- Have or have had blood clots, a stroke or a heart attack
- Have liver disease or a known bleeding or clotting disorder
- Are pregnant or think you may be pregnant
- Are allergic to any ingredient in the product
Some progesterone capsules contain peanut oil. Do not take them if you’re allergic to peanuts.
How should I use them?
- Patch: apply to clean, dry skin on your lower belly or hip once a week, using a new spot each time.
- Pill: take one tablet by mouth each day.
- Estradiol Cream: rub into your inner arm or thigh once a day, let it dry, then wash your hands. Keep the area away from children, partners and pets until fully absorbed.
- Vaginal Cream: insert with the applicator as directed, usually daily at first, then a few times a week.
- Progesterone: take one capsule at bedtime, since it can cause drowsiness or dizziness.
What should I tell my provider first?
Tell your provider about every medicine you take, including over-the-counter supplements, and if you have or have had: breast or uterine problems, high blood pressure, high cholesterol or triglycerides, diabetes, migraines, gallbladder disease, liver or kidney problems, thyroid problems, asthma, seizures, lupus, or if you smoke. Tell your provider if you are planning surgery or will be on bed rest.
What are the most serious side effects?
If you have a medical emergency, call 911. Get medical help right away if you have:
- Chest pain or shortness of breath
- Pain, swelling or redness in your leg
- A sudden severe headache, vision changes, trouble speaking, or weakness or numbness on one side
- A new breast lump
- Unusual vaginal bleeding
- Yellowing of the skin or eyes
What are the most common side effects?
Headache, breast tenderness, spotting or irregular bleeding, nausea, bloating, mood changes and, with the patch, skin irritation where it’s applied. Progesterone can cause drowsiness or dizziness.
Other important information
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
This summary provides basic information about estradiol and progesterone but does not include everything known about these medicines. Your ReformedRx provider can answer any questions about side effects before you start treatment. Please also read the information that comes with your prescription each time it’s filled.
Licensed providers make all consultation and prescribing decisions. Purchasing does not guarantee a prescription. Prescriptions are issued only after a licensed provider reviews your information and determines that treatment is appropriate.
We serve patients in 46 states. We do not currently provide services in Alaska, Mississippi, New Jersey or Texas. Availability can vary by product, depending on whether the dispensing pharmacy is licensed to ship to your state.
