Estradiol Cream
A transdermal estradiol cream, applied once daily to relieve menopause symptoms such as hot flashes and night sweats.
- Apply once a day
- Strength set by your provider
- Compounded medication. Not FDA-approved.
Card authorized at checkout. Charged only if a provider approves.
Product images are for illustration only. Actual packaging may vary.
The Estradiol Cream is a compounded prescription drug that contains estradiol and is used to treat menopause symptoms such as hot flashes and night sweats. Compounded drugs are permitted to be prescribed under federal law, but are not FDA-approved and do not undergo FDA safety, effectiveness, or manufacturing review. Estrogen therapy can increase the risk of blood clots, stroke, heart attack, breast cancer and, in women with a uterus who do not also take progesterone, endometrial cancer. The cream can transfer to others through skin contact. See Important Safety Information.
The short version.
What is the Estradiol Cream?
A compounded transdermal estradiol cream applied to the skin once daily to treat menopause symptoms, including hot flashes, night sweats and sleep disturbances.
What makes the Estradiol Cream different?
Because estradiol is absorbed through the skin, it bypasses first-pass metabolism in the liver, and your provider can adjust the dose as needed.
How much does the Estradiol Cream cost?
Starting at $66.33/mo with the 3-month supply ($199 billed every 3 months), or $110 monthly. No membership fee.
Three simple
steps.
Get prescribed
Complete a secure online visit, and a licensed provider reviews your health history.
Apply once a day
Apply the prescribed dose to clean, dry skin on the inner arm or thigh. Allow it to dry completely, then wash your hands with soap and water.
Check in
Your provider follows your progress and adjusts your plan if needed.
From your phone
to your door.
Your card is authorized at checkout, but you are only charged if a provider approves your treatment.
Complete a short online visit with a few health questions
Hear from your provider
Most orders arrive within a few business days of approval, with tracking sent when your order ships
Begin treatment, with your care team a message away
Find the
right fit.
Your provider confirms which option is appropriate for you.
| Treatment | What it is | Price |
|---|---|---|
| Estradiol Patch Featured | Estradiol · weekly skin patch | Starting at $109.67/moBilled $329 every 3 months · Recommended · 3-month supply (or $133 monthly) |
| Estradiol Pill | Estradiol · daily tablet | Starting at $59.67/moBilled $179 every 3 months · Recommended · 3-month supply (or $99 monthly) |
| Estradiol Cream | Compounded estradiol · daily skin cream | Starting at $66.33/moBilled $199 every 3 months · Recommended · 3-month supply (or $110 monthly) |
| Vaginal Estradiol Cream | Estradiol 0.1 mg/g · vaginal cream with applicator | Starting at $63/moBilled $189 every 3 months · Recommended · 3-month supply (or $110 monthly) |
| Progesterone | Progesterone · capsule at bedtime | Starting at $66.33/moBilled $199 every 3 months · Recommended · 3-month supply (100 mg) (or $99 monthly) |
Questions, answered.
Can it affect my children, partner or pets?
Yes. Estradiol can transfer to others through skin contact. Allow the application site to dry completely, wash your hands with soap and water, and keep the area covered until the cream is fully absorbed.
Is this the same as the vaginal cream?
No. This cream treats whole-body symptoms like hot flashes. The vaginal cream treats dryness and discomfort.
Do I need progesterone too?
If you have a uterus, yes. Estrogen taken alone can cause the uterine lining to thicken (endometrial hyperplasia), which increases the risk of endometrial cancer. Progesterone protects the uterine lining. If you've had a hysterectomy, your provider will advise whether you need it.
Do I need a prescription?
Yes. Complete a short online visit to see if this treatment is right for you. A licensed provider reviews your answers and decides whether it's appropriate to prescribe.
Who makes the treatment decision?
Licensed providers make all consultation and prescribing decisions. Purchasing does not guarantee a prescription. Prescriptions are issued only after a licensed provider reviews your information and determines that treatment is appropriate.
What the research says.
The studies discussed here may involve different formulations, doses, delivery methods, or patient populations from the treatment offered. They do not establish the safety or effectiveness of this specific compounded product. Compounded medications are not FDA-approved; FDA does not review their safety, effectiveness, or quality before marketing.
The 2022 hormone therapy position statement of The North American Menopause Society.
What was studied. A professional evidence synthesis (not a single trial) of menopausal hormone therapy.
What researchers found. Menopausal hormone therapy is the most effective treatment for hot flashes and night sweats. Low-dose vaginal estrogen is an established treatment option for menopause-related vaginal dryness and discomfort when nonprescription measures are insufficient.
How it relates to this treatment. Your clinician reviews your symptoms, medical history, and individual risks to determine whether treatment is appropriate. Patients with a uterus generally need endometrial protection (progesterone) when using systemic estrogen. Bundles combine individual treatments; the bundles themselves have not been studied as products.
“The 2022 hormone therapy position statement of The North American Menopause Society.” Menopause, 2022. PMID: 35797481.
What to know before starting Estradiol Cream.
Other ways
we can help.
The Estradiol Cream is a compounded prescription drug that contains estradiol and is used to treat menopause symptoms such as hot flashes and night sweats. Compounded drugs are permitted to be prescribed under federal law, but are not FDA-approved and do not undergo FDA safety, effectiveness, or manufacturing review. Estrogen therapy can increase the risk of blood clots, stroke, heart attack, breast cancer and, in women with a uterus who do not also take progesterone, endometrial cancer. The cream can transfer to others through skin contact.
We serve patients in 46 states. We do not currently provide services in Alaska, Mississippi, New Jersey or Texas. Availability can vary by product, depending on whether the dispensing pharmacy is licensed to ship to your state.
Licensed providers make all consultation and prescribing decisions. Purchasing does not guarantee a prescription. Prescriptions are issued only after a licensed provider reviews your information and determines that treatment is appropriate. Your card is authorized at checkout, but you are only charged if a provider approves your treatment.