Skin Renewal Complex
Helps support collagen production and soften fine lines for smoother-looking skin.
- Prescription retinoid plus estriol
- Applied at night
- Compounded medication. Not FDA-approved.
Card authorized at checkout. Charged only if a provider approves.
Product images are for illustration only. Actual packaging may vary.
The Skin Renewal Complex is a compounded prescription drug that contains tretinoin and estriol and is used to help improve the appearance of fine lines and skin texture. Compounded drugs are permitted to be prescribed under federal law, but are not FDA-approved and do not undergo FDA safety, effectiveness, or manufacturing review. Do not use it if you are pregnant, trying to become pregnant or breastfeeding. See Important Safety Information.
The short version.
What is the Skin Renewal Complex?
A compounded cream combining estriol and tretinoin, a prescription retinoid, used to help improve the appearance of fine lines and skin texture.
What makes the Skin Renewal Complex different?
It combines a retinoid that increases skin cell turnover with estriol, a mild estrogen that supports skin thickness and hydration.
How much does the Skin Renewal Complex cost?
Starting at $80.67/mo with the 3-month supply ($242 billed every 3 months), or $110 monthly. No membership fee.
Three simple
steps.
Get prescribed
Complete a secure online visit, and a licensed provider reviews your skin goals and health history.
Apply at night
Use a pea-sized amount on clean, dry skin, as your provider directs.
Stay consistent
Use it as directed. Response to treatment varies from person to person.
From your phone
to your door.
Your card is authorized at checkout, but you are only charged if a provider approves your treatment.
Complete a short online visit with a few health questions
Hear from your provider
Most orders arrive within a few business days of approval, with tracking sent when your order ships
Begin treatment, with your care team a message away
Find the
right fit.
Your provider confirms which option is appropriate for you.
| Treatment | What it is | Price |
|---|---|---|
| GHK-Cu Peptide Skin Complex Featured | GHK-Cu cream · 30 g | Starting at $99.67/moBilled $299 every 3 months · 90-day supply · online provider visit included |
| Skin Renewal Complex | Estriol + tretinoin cream · 30 g | Starting at $80.67/moBilled $242 every 3 months · 90-day supply · online provider visit included (or $110 monthly) |
Questions, answered.
Will my skin peel at first?
Some dryness, redness or peeling is common in the first few weeks as your skin adjusts.
Do I need sunscreen?
Yes, every day. Tretinoin makes skin more sensitive to sun.
Can I use it during pregnancy?
No. Stop and tell your provider if you become pregnant.
Do I need a prescription?
Yes. Complete a short online visit to see if this treatment is right for you. A licensed provider reviews your answers and decides whether it's appropriate to prescribe.
Who makes the treatment decision?
Licensed providers make all consultation and prescribing decisions. Purchasing does not guarantee a prescription. Prescriptions are issued only after a licensed provider reviews your information and determines that treatment is appropriate.
What the research says.
The studies discussed here may involve different formulations, doses, delivery methods, or patient populations from the treatment offered. They do not establish the safety or effectiveness of this specific compounded product. Compounded medications are not FDA-approved; FDA does not review their safety, effectiveness, or quality before marketing.
Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials,
What was studied. A review of seven randomized trials of topical tretinoin.
What researchers found. Randomized clinical trials have found that topical tretinoin can improve visible signs of sun-related skin aging, including fine wrinkles and uneven pigmentation.
How it relates to this treatment. This does not prove that adding estriol improves results or that a compounded combination performs the same way. Topical estrogen research (Schmidt et al., 1996, PMID 8876303) is preliminary.
“Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials,” 2022.
What to know before starting Skin Renewal Complex.
Other ways
we can help.
The Skin Renewal Complex is a compounded prescription drug that contains tretinoin and estriol and is used to help improve the appearance of fine lines and skin texture. Compounded drugs are permitted to be prescribed under federal law, but are not FDA-approved and do not undergo FDA safety, effectiveness, or manufacturing review. Do not use it if you are pregnant, trying to become pregnant or breastfeeding.
We serve patients in 46 states. We do not currently provide services in Alaska, Mississippi, New Jersey or Texas. Availability can vary by product, depending on whether the dispensing pharmacy is licensed to ship to your state.
Licensed providers make all consultation and prescribing decisions. Purchasing does not guarantee a prescription. Prescriptions are issued only after a licensed provider reviews your information and determines that treatment is appropriate. Your card is authorized at checkout, but you are only charged if a provider approves your treatment.