GLP-1 medications have changed how clinicians approach weight care. This guide explains, in plain language, what they are, how semaglutide and tirzepatide differ, and what to expect if your provider recommends one.
What is GLP-1?
GLP-1 (glucagon-like peptide-1) is a hormone your gut releases after you eat. It signals fullness to the brain, slows how quickly the stomach empties and helps regulate blood sugar. GLP-1 medications mimic this hormone, which is why many people notice quieter hunger and feel full sooner.
Semaglutide: one pathway
Semaglutide acts on the GLP-1 receptor. It’s taken once weekly and started at a low dose, which your provider increases gradually so your body can adapt.
Tirzepatide: two pathways
Tirzepatide is a dual GIP and GLP-1 receptor agonist. It mimics two hormones your gut naturally releases after eating. Their receptors are found in the brain, gut and pancreas, where they play a role in appetite, blood sugar and metabolism.
Which one is right for me? Your provider decides, based on your health history, current medications, goals and how you respond. Neither is “better” for everyone.
What to expect
- You start on a low dose, adjusted month by month.
- Common side effects include nausea, reduced appetite and digestive changes, usually strongest when starting or increasing a dose.
- Results build gradually and vary between people.
- Strength training and enough protein help protect muscle while you lose weight.
About compounded GLP-1s
ReformedRx offers compounded semaglutide and tirzepatide, prepared by certified U.S. pharmacies in FDA-registered facilities. Compounded medications are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality before they are marketed.
Sources and clinical references will be added by the ReformedRx clinical team before publishing.
